Munich, Germany and San Francisco, USA, October 20, 2025 – CatalYm today announced updated long-term data from its ongoing GDFATHER-1/2a trial (NCT04725474) at the European Society of Medical Oncology (ESMO) Congress 2025. The data provide further evidence that Growth Differentiation Factor-15 (GDF-15) blockade by visugromab can reverse resistance to PD-(L)1 treatment in patients with advanced solid tumors and deliver durable responses in patients who have relapsed or progressed on prior checkpoint inhibitor treatment.

Munich, Germany and San Francisco, USA, October 17, 2025 – CatalYm today presented compelling primary results from the Phase 2 GDFATHER-NEO trial in an oral late-breaking session at the European Society of Medical Oncology (ESMO) Congress 2025. The data demonstrated that Growth Differentiation Factor-15 (GDF-15) blockade by visugromab enhanced the efficacy of PD-1 inhibition by nivolumab as a neoadjuvant therapy in muscle-invasive bladder cancer (MIBC), with a similar safety profile compared to nivolumab plus placebo.

Munich, Germany and San Francisco, USA, September 30, 2025 – CatalYm today announced that the first patient has been dosed in the randomized Phase 2b GDFATHER-NSCLC-01 trial (NCT07098988). The trial investigates the efficacy and safety of the company's anti-GDF-15 antibody visugromab, in combination with standard-of-care chemoimmunotherapy, compared to placebo plus chemoimmunotherapy, as a first-line treatment for patients with newly diagnosed metastatic non-squamous non-small cell lung cancer (NSQ mNSCLC).

MUNICH & SAN FRANCISCO--(BUSINESS WIRE) September 23, 2025 – CatalYm, a world-leader in neutralizing GDF-15 in cancer and cachexia, today announced two upcoming oral presentations highlighting the company's lead-candidate visugromab at the European Society of Medical Oncology (ESMO) Congress, being held October 17^th - 21^st, 2025, in Berlin, Germany.

Munich, Germany and San Francisco, USA, September 15, 2025 – CatalYm, a world-leader in neutralizing GDF-15 in cancer and cachexia, today announced changes to its executive leadership team to support its next stage of growth. The appointments of Clinton Musil as Chief Financial Officer and Chief Business Officer; Sujata Rao, MD, as Chief Medical Officer; Heike Krupka, PhD, as Chief Development Officer and Andrea Goddard as Chief Technology Officer represent a significant addition to the company's international development expertise.

Amsterdam, the Netherlands, September 09, 2025 – Scenic Biotech, a pioneer in the field of modifier therapies for severe diseases, today announced the appointment of Roland W. Bürli, PhD, as Chief Scientific Officer (CSO), effective September 1, 2025. Dr. Bürli brings more than 25 years of experience in drug development and has held senior leadership roles across pharma and biotech companies.

Amsterdam, the Netherlands, September 03, 2025 – Scenic Biotech, a pioneer in the field of modifier therapies for severe diseases, today announced a publication in Nature on the role of ABHD18 as a missing link in the cardiolipin biosynthesis pathway. Cardiolipin is the signature phospholipid essential for mitochondrial function and implicated in both rare and common diseases. In a collaboration between Scenic and Dr. Jason Moffat's team at The Hospital for Sick Children (SickKids) in Toronto, the study aimed to identify modifier genes for Barth Syndrome (BTHS), an inborn error of cardiolipin metabolism, characterized by early onset cardiac and skeletal myopathy.

Amsterdam, the Netherlands, August 26, 2025 – Scenic Biotech, a pioneer in modifier therapies for severe diseases, today announced a license and research agreement with Alnylam Pharmaceuticals, Inc. (NASDAQ: ALNY) to leverage Scenic's Cell-Seq platform for discovering novel targets for RNAi therapeutics.

Schlieren / Zurich, Switzerland, 19 August, 2025 – Memo Therapeutics AG ("MTx") has published Phase I clinical data in Clinical and Translational Science, highlighting the safety, tolerability, and pharmacokinetics (PK) of its lead clinical asset, potravitug, a highly potent human monoclonal antibody targeting BK polyomavirus ("BKPyV").

Schlieren / Zurich, Switzerland, 25 July, 2025 – Memo Therapeutics AG ("MTx"), a late-stage biotech company translating unique immune responses into superior medicines to treat viral infections and cancer, today announced results from its Phase II clinical trial evaluating potravitug, a highly potent human BK polyomavirus ("BKPyV")-neutralizing monoclonal antibody, for the treatment of BKPyV infection in kidney transplant recipients ("KTR").