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CatalYm: Positive Phase 2a Outcome

Munich, Germany, December 6, 2023 – CatalYm announced that maturing Phase 2a results from its ongoing GDFATHER-2 trial (GDF-15 Antibody-mediaTed Human Effector Cell Relocation Phase 2) (NCT04725474) were presented today in an oral presentation at the European Society for Medical Oncology (ESMO) Immuno-Oncology Congress 2023 in Geneva, Switzerland.

Memo Therapeutics: CEO Erik van den Berg

Schlieren / Zurich, Switzerland – November 16, 2023 – Memo Therapeutics AG ("MTx"), a late-stage biotech company developing best-in-class therapeutic antibodies, announced today the appointment of Erik van den Berg as Chief Executive Officer (CEO).

Memo Therapeutics: CHF 25 Million Financing

Schlieren / Zurich, Switzerland – November 2, 2023 – Memo Therapeutics AG ("MTx"), a late-stage biotech company developing best-in-class therapeutic antibodies, announced today the closing of a CHF25 million Series C financing led by Pureos Bioventures.

Rejuvenate Biomed: Positive results

Diepenbeek, Belgium, October 4, 2023 – Rejuvenate Biomed NV ("Rejuvenate Biomed"), a clinical-stage company dedicated to advancing therapeutics to delay the onset of age-related diseases, today announced the successful completion of a 6-week clinical proof-of-mechanism study with lead candidate RJx-01. RJx-01, a novel combination drug comprising galantamine and metformin, demonstrated positive results in 42 elderly male subjects with disuse-induced muscle atrophy.

CatalYm in Nature Communications

Munich, Germany, July 20, 2023 – CatalYm today announced the publication of preclinical data in Nature Communications under the title "Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment". The study reveals a central role of GDF-15 in the resistance of tumors to current immunotherapy.

OncoDNA: Closing Round C financing

July 3, 2023 – OncoDNA, a genomic and theranostic company specializing in precision medicine for the treatment of patients with cancer and genetic diseases, today announced the closing of a Round C financing of 6,5 M€, entirely subscribed by its current shareholders.

Memo Therapeutics: U.S. Pivotal Phase II/III

Schlieren/Zurich, Switzerland, June 22, 2023 – Memo Therapeutics AG ("MTx") announced today that the first patient has been enrolled in a pivotal, multicenter U.S. Phase II/III trial of AntiBKV, MTx's antibody therapeutic that targets BK polyomavirus ("BKV") infection in renal transplant patients. MTx recently received Fast Track designation for AntiBKV from the U.S. Food and Drug Administration ("FDA").

CatalYm Announces Initial Data

Munich, Germany, June 6, 2023 – CatalYm today announced first Phase 2a data from its ongoing GDFather-2 trial (GDF-15 Antibody-mediaTed Human Effector Cell Relocation Phase 2) (NCT04725474) at the American Society of Clinical Oncology (ASCO) Annual Meeting 2023 in Chicago, Illinois. The early data presented during today's oral "Developmental Therapeutics-Immunotherapy" session revealed lasting and confirmed responses in several solid tumor types investigated following treatment with visugromab and the anti-PD-1 inhibitor nivolumab.

Topas Initiates Phase 2a Clinical Trial

Hamburg, Germany, May 25, 2023 – Topas Therapeutics, a clinical stage biotech company developing novel antigen-specific immune tolerance therapies to treat autoimmune disorders, announced today the launch of a Phase 2a clinical study (NCT05660109) evaluating the safety, tolerability and pharmacodynamics of TPM502 in patients with celiac disease.

Memo Therapeutics: FDA Designation

Schlieren/Zurich, Switzerland – May 2, 2023 – Memo Therapeutics AG ("MTx") announced today that the U.S. Food and Drug Administration ("FDA") has granted Fast Track designation to AntiBKV, MTx's lead antibody therapeutic that targets BK polyomavirus ("BKV") infection commonly seen in renal transplant patients.

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