Schlieren / Zurich, Switzerland, and Osaka, Japan, November 1st, 2022 – Memo Therapeutics AG ("MTx"), an innovator in the field of antibody discovery and development, announced today the signing of a research and development collaboration agreement with Ono Pharmaceutical Co. Ltd ("Ono"). Under the terms of the agreement, MTx will leverage its best-in-class microfluidic single-cell molecular cloning and screening technologies to discover antibodies for immuno-oncology targets.

Collaborative study supported by GSK to assess potential improvement to standard of care will be led by University of California Cancer Consortium

Munich, Germany, September 26, 2022 – CatalYm today announced that it has received Investigational New Drug (IND) clearance from the United States Food and Drug Administration (FDA) to expand its ongoing Phase 2 clinical program to include clinical trial centers in the U.S. The ongoing GDFATHER-2 program (GDF-15-neutralizing antibody-mediated human effector cell relocation) is evaluating the company's lead candidate, visugromab in combination with an anti-PD1 antibody in patients with advanced solid tumors that are relapsed/refractory to prior anti-PD1/-PD-L1 treatment. Visugromab is a monoclonal antibody that neutralizes GDF-15, a key immunosuppressor, which has been shown to prevent T cell migration into tumors, enabling cancerous cells to evade the immune system.

Antibody addresses high unmet medical need in large and rapidly growing kidney transplant market

Gosselies/Belgium, 29 March 2022 – We are thrilled to announce today a new partnership with Synlab, Europe's leading clinical laboratory and medical diagnostic services provider.

Diepenbeek, Health Campus, Belgium, 29 March 2022 – Rejuvenate Biomed NV ("Rejuvenate"), a biomedical company developing novel combination drugs for age-related diseases, today provides an update on its development pipeline and strategy.

Amsterdam, The Netherlands, 10th March 2022 – Scenic Biotech BV ("Scenic"), a pioneer in the discovery of genetic modifiers to enable the development of disease modifying therapeutics for rare genetic disorders and other devastating illnesses, is pleased to announce it has closed a Series A financing of ~$31 million (€28 million).

Munich, Germany, March 1st, 2022 – CatalYm today announced treatment of the first patients in a series of phase 2a cohorts targeting solid tumors, initiating phase 2 development of CTL-002. The trial will evaluate the safety and efficacy of the company's lead product candidate, the GDF-15 neutralizing antibody CTL-002 (visugromab), at the confirmed target dose in five cohorts in combination with nivolumab in patients that are relapsed/refractory to anti-PD1/-L1 treatment and in one cohort that is anti-PD-1/-L1 naïve. All six target tumor types were identified by translational research data to exhibit GDF-15-mediated tumoral immunosuppression.

Schlieren, Switzerland – February 16, 2022 – Memo Therapeutics AG ("MTx"), an innovator in the field of antibody discovery and development, announced today the close of an oversubscribed Series B financing round led by Swisscanto Invest at CHF37 million after securing an additional CHF23 million from a combination of strategic and financial investors, including Adjuvant Capital, Fresenius Medical Care Ventures, GF Group, Verve Ventures, Vesalius Biocapital and Zürcher Kantonalbank.

Hamburg, February 15, 2022 – Topas Therapeutics GmbH (Topas), a private biotechnology company developing immune tolerance-inducing drugs to treat and potentially cure a variety of autoimmune diseases, today announced the appointment of Cristina de Min, M.D., as Chief Medical Officer. In this position, she will be responsible for Topas' clinical development programs based on its proprietary Topas Particle Conjugates technology platform, with a focus on lead product candidate, TPM203, currently in clinical development for the treatment of pemphigus vulgaris, and TPM502 for the treatment of celiac disease, which is expected to enter the clinic in the coming months.